highly significantp = 2 × 10 − 16
To determine the significance of the results, we fit three one-way analysis of variance (ANOVA) models comparing ssGSEA scores of CD4, CD8, and macrophage cell type markers, which were all highly significant ( p = 2 × 10 − 16 , p = 6.28 × 10 − 15 and p = 2 × 10 − 16 , respectively).