The prognostic significance of weight loss in chronic obstructive pulmonary disease-related cachexia: a prospective cohort study.

There are likely to be significant mechanistic differences to explain body composition abnormalities in these groups with implications for the development of anabolic agents and the identification of patient phenotypes that respond best to them. 28 In summary, although the prevalence of cachexia and pre‐cachexia in outpatients with stable COPD is low, these phenotypes are associated with important clinical manifestations including poorer exercise tolerance and greater respiratory disability.

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