highly significantP value ≤ 0.001
The chemical-genetic interaction of the positive control methyl methanesulfonate (MMS), a well-characterized antifungal agent that damages DNA [ 28 ], demonstrated a highly significant enrichment ( P value ≤ 0.001) for cellular response to DNA damage stimulus, confirming a successful HIP-HOP assay procedure and accurate post-sequencing data analysis.