nearly reached significanceP = 0.06
With combined analysis of sensitivity and specificity through area under the curve (AUC), AD-1 significantly outperformed gram stain (AUC = 1.0 versus AUC = 0.55, P < 0.001) and nearly reached significance compared to culture (AUC = 1.0 versus AUC = 0.75, P = 0.06) (Fig. 2 ).