highly significantp < 0.001
Specifically, we could demonstrate an inverse association with renal function as displayed by a highly significant correlations with the glomerular filtration rate of cystatin C (r = − 0.675, p < 0.001), cystatin C (r = 0.675, p < 0.001), creatinine (r = 0.629, p < 0.001) and urea (r = 0.623, p < 0.001) serum concentrations (Table 3 ), indicating renal clearance of MR-proANP [ 45 ].