The predictive power of NPTX2 for cognitive progression was at least comparable to that of Nfl and was consistent across measures of memory, global cognition, and CDR ( Supplementary Table 4 ), whereas Nfl had strong predictive value for ADAS-cog and borderline significance for other tests.
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Synaptic biomarkers in CSF aid in diagnosis, correlate with cognition and predict progression in MCI and Alzheimer's disease.
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