Clinical relevance of neutralizing antibodies in botulinum toxin long-term treated still-responding patients with cervical dystonia.

However, when the mean values of the doses of the last 10 BoNT-injections ( Figure 1B ) were compared, a highly significant ( p < 0.001) difference was found between ELISA-positive (MV: 850 uDU, SD: 164 uDU) and ELISA-negative (MV: 761 uDU, SD: 177 uDU) patients.

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For other clinical data, a positive trend was found (TSUI-score: r = 0.310, n.s.; PSSTE: r = 0.284, n.s.; total CDQ24: r = 0.250, n.s.), which, however, did not reach the level of significance ( p = 0.05).

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