Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice.

However, when these cohorts were analyzed by gender, we observed a significant reduction of soluble Aβ 42 in female mice received mixed vaccine, but not AV-1959R/A alone (Additional file 1 : Figure S2a), while male mice showed significant reduction of soluble Aβ 42 in AV-1959R/A cohort and only a slight trend of reduction in AV-1959R/1980R/A cohort (Additional file 1 : Figure S3a), thus making this difference non-significant when combined female/male groups were compared (Fig. 5a ) .

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