Focused ultrasound enhanced intranasal delivery of brain derived neurotrophic factor produces neurorestorative effects in a Parkinson's disease mouse model.

Sci Rep · 2019 · PMC6920380 · PMID 31852909

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a nonsignificant trendno p-value reported

However, the FUS-induced BBB opening group did show a nonsignificant trend, due to insufficient power, toward greater CW rotations, suggesting a potential improvement in the DA pathway with FUS-induced BBB opening, as reported in prior studies 41 .

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an increasing trendno p-value reported

However, when comparing the average baseline DAB ratio for the MPTP only group, there is an increasing trend in the FUS only (ratio of 1.04) and IN + FUS groups (ratio of 1.06) within the SNc.

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