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Age-period-cohort analysis with a constant-relative-variation constraint for an apportionment of period and cohort slopes.

PLoS One · 2019 · PMC6922428 · PMID 31856261

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an increasing trendno p-value reported
The period effect derived from our CRV method for prostate cancer incidence in the United States is consistent with previous studies [ 38 – 41 ], that is, an increasing trend since 1973, a peak at 1992, and a declining trend thereafter.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.