Differential expression of ghrelin and GHSR via the mTOR pathway during the dynamic carcinogenic process involving oral, potentially malignant disorders.

There were significant differences between the two groups with normal ( P = 0.04) and moderate dysplasia ( P = 0.025), extremely significant differences with mild dysplasia ( P = 0.00), and no significant differences with severe dysplasia ( P = 0.38) and oral cancer ( P = 0.342) ( Figure 4 A).

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Quantitative detection of mTOR, ghrelin, and receptor RNA in human oral mucosal cell lines during carcinogenesis The levels of ghrelin, GHSR1 β, and mTOR RNA showed an increasing trend in the HOK, LEUK1, and CAL27 cell lines, respectively; however, the level of GHSR1α expression in the CAL27 cell line showed a peak value, which was lower than the LEUK1 cell line, but higher than the LEUK1 cell line ( Figure 5 A).

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