PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth.

When the comparison was performed within each grade, grades 1 and 2 showed highly significant positive correlations between these losses ( p = 0.00077 and p = 0.0093, respectively), while grade 3 did not show any and grade 4 showed a weak but significant correlation ( p = 0.044) (Fig. 7b and Supplementary Fig. 7 ).

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