Multifocal Signal Modulation Therapy by Celecoxib: A Strategy for Managing Castration-Resistant Prostate Cancer.

The combined STRING analysis of the CGS here identified and the 172 genes and/or proteins previously described as differentially expressed in MDB and PDB cells during castration resistance development [ 10 ] resulted in a high number of interactions and a highly significant protein–protein interaction (PPI) enrichment p -value ( Figure S2A ) mainly determined by AR and AKT1 ( Figure S2B ).

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