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A Positive Tetraspanin 8 (TSPAN8)/β-Catenin Regulatory Loop Enhances the Stemness of Colorectal Cancer Cells.

Med Sci Monit · 2019 · PMC6929559 · PMID 31838484

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an increasing trendno p-value reported
Every year, there are more than 1 million new cases, showing an increasing trend.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.