In the case of the much larger mandelalide A, configuration 2 p can readily be distinguished from 2 r but in the case of the epimers 2 p and 11-epi - 2 p the difference is barely significant.
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Conformational Investigations in Flexible Molecules Using Orientational NMR Constraints in Combination with <sup>3</sup><i>J</i>-Couplings and NOE Distances.
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