Cumulative solar ultraviolet radiation exposure and basal cell carcinoma of the skin in a nationwide US cohort using satellite and ground-based measures.

In general linear models fit better than the log-linear model, as shown by the AIC statistics (Table 2 , Additional file 1 : Table S2). Table 3 demonstrates that there is at best borderline significant variation of excess absolute risk by time since exposure ( p = 0.279) or with age at exposure ( p = 0.085); this contrasts with more pronounced and significant variation of relative risk both with time since exposure ( p = 0.034), and with age at exposure ( p = 0.012) with relative risk particularly large for the period 10–14 years after UVR exposure and for exposures under the age of 25 (Table 4 ).

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There are no significant differences between the sexes in excess absolute risk ( p = 0.152, results not shown), although there are stronger indications that the excess relative risk for males is higher (by about 25%) than for females ( p = 0.008, results not shown). Discussion In this nationwide US study of radiologic technologists, we observed that there were highly significant increasing trends of BCC risk with increasing UVR cumulative radiant exposure, using two independent measures of UVR, one ground based and the other derived from satellite data.

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