Genetic biomarkers in the VEGF pathway predicting response to anti-VEGF therapy in age-related macular degeneration.

BMJ Open Ophthalmol · 2019 · PMC6936450 · PMID 31909188

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

failed to reach significancep=0.07so close (0.05 < p ≤ 0.1)

In contrast, although the change in BCVA was higher in responders than in non-responders, this failed to reach significance (p=0.07), in line with earlier reports suggesting that changes in BCVA poorly reflect therapeutic response. 26 27 Age and gender distributions between responders and non-responders were similar.

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borderline significantno p-value reported

Indeed, the overlap of the seven associations detected after 3 months with associations after 12 months was limited: Only one SNP, rs7691507, was also significant (p<0.05) after 12 months, while two other SNPs were borderline significant (rs3025035 and rs2305945, with P-values of respectively, 0.057 and 0.053) and four SNPs were not significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.