Enrichment analysis revealed that common genes, with increased expression in APOEε2/c , clustered primarily in highly significant GO terms involved in translation, proteasome-mediated ubiquitin-dependent protein catabolic process, response to unfolded protein, signal recognition particle (SRP)-dependent protein targeting, endoplasmic reticulum (ER) translational translocation, ER stress response, autophagy, and mitochondrial electron transport.
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APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain.
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