Barely Significant
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Regulation of muscle and metabolic physiology by hypothalamic erythropoietin independently of its peripheral action.

Mol Metab · 2020 · PMC6938905 · PMID 32029230

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highly significantno p-value reported
Compared with young healthy conditions, we appreciated that these effects of EPO treatment were more evident in middle-aged mice, suggesting that central EPO could be highly significant therapeutically.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.