Neutrophils and neutrophil extracellular traps enhance venous thrombosis in mice bearing human pancreatic tumors.

3 For instance, we found an association between levels of circulating extracellular vesicle tissue factor activity and VTE in pancreatic cancer in two studies and a borderline significance in a third study. 4 – 6 Circulating tumor-derived, tissue factor-positive extracellular vesicles are also observed in mice bearing human pancreatic tumors. 7 – 10 Importantly, we have shown that these tumor-derived, human tissue factor-positive extracellular vesicles enhance venous thrombosis in mi

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