BCR-ABL1 + BaF3 cells plated on E-selectin in the presence of GMI-1271 also exhibited increased expression of the cell cycle promoter cyclin dependent kinase (CDK) 6 ( P <0.0001) ( Figure 4F ), a possible trend towards increased nuclear CDK4 ( Online Supplementary Figure S8D, E ), which has been associated with cell cycle progression, and decreased expression of the cell cycle inhibitor p16 (or cyclin dependent kinase inhibitor 2A) ( P <0.0001) ( Figure 4G ).
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The vascular bone marrow niche influences outcome in chronic myeloid leukemia <i>via</i> the E-selectin - SCL/TAL1 - CD44 axis.
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