Effect of Aluminum Adjuvant and Preservatives on Structural Integrity and Physicochemical Stability Profiles of Three Recombinant Subunit Rotavirus Vaccine Antigens.

A decreasing trend was observed in antigen binding with the addition of higher concentrations of phosphate (e.g., ∼40% of P[8] bound in 10 mM phosphate, Fig. 1b ) as the surface charge of AH became negative (as measured by ZP values).

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