Recombinant Subunit Rotavirus Trivalent Vaccine Candidate: Physicochemical Comparisons and Stability Evaluations of Three Protein Antigens.

Chemical Stability Profiles and Comparisons of the Three NRRV Antigens After subjecting the 3 NRRV antigens to elevated pH and temperature stress (pH 9.0, 25°C for 6 days), an increasing trend in molecular mass was observed for each protein by intact mass analysis compared to pH 7.2, 4°C control samples ( Fig. 6a ).

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