Estimating dose-response for time to remission with instrumental variable adjustment: the obscuring effects of drug titration in Genome Based Therapeutic Drugs for Depression Trial (GENDEP): clinical trial data.

In the standard Cox model, while, as expected, baseline MADRS score was highly significant, with log HR = − 0.051 (95% CI = − 0.079 to − 0.023) implying higher severity being associated with longer time to remission, higher relative dose was not significantly associated and the estimated coefficient also implied a decreasing log HR = − 0.180 (95% CI = − 0.933 to 0.573).

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Sex and age showed marginally significant associations, but, perhaps surprisingly, prior duration and age of onset of depression and BMI were unrelated to relative dose.

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