The Trends in Opioid Use in Castile and Leon, Spain: A Population-Based Registry Analysis of Dispensations in 2015 to 2018.

Most importantly, increases in the use of opioid analgesics among daily users (2.6 times higher) and chronic users (1.5% higher) were noted during the covered period ( Figure 3 ), that supporting the overall increase in opioid use observed (1.5% higher), although the growths in percentage of the use of given formulations did not achieve significance ( Table 2 ).

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