While other neurontransmitters such as 5-HT, 5-HIAA and NE were almost not significant difference between the two types (DEC1 +/+ and DEC1 -/- ) of mice at the age of 3, 6 and 12 months ( Supplementary Figure 2 ).
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The loss of dopaminergic neurons in DEC1 deficient mice potentially involves the decrease of PI3K/Akt/GSK3β signaling.
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