Biophysical classification of a <i>CACNA1D</i> de novo mutation as a high-risk mutation for a severe neurodevelopmental disorder.

4 a, b, mutated channels caused a marked and highly significant increase of I Ca over the first 300 ms of the depolarization compatible with enhanced channel activity suitable to support upstate potentials during this time period (for details, see legend to Fig. 4 ).

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