highly significantp < 0.05
As for PLCL controls, a highly significant increase, (p < 0.05), in the thee investigated values were reported within 30 min of their incubation in both test media; which could be justified as per the role of PEG in maintaining lipomer stability, both in-vitro ; by reducing aggregation, and in-vivo ; by evading RES and immune system recognition, in addition to preventing protein adsorption, and biofouling ( Moghimi and Szebeni, 2003 ).