Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue.

PLoS One · 2020 · PMC6953873 · PMID 31923274

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hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

borderline significancep = 0.06so close (0.05 < p ≤ 0.1)

However, the ratio of Kyn to Trp concentrations was higher in fatigued (mean 0.029; 95% CI 0.025–0.033) than non-fatigued survivors (mean 0.026; 95% CI 0.025–0.028) with a borderline significance level of p = 0.06 ( S3 Table ; Fig 3 ).

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highly significantno p-value reported

PAr substituted IL-6 in the model due to highly significant bivariate correlations.

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of borderline significanceno p-value reported

Repeating the analyses for differences between fatigued and non-fatigued survivors after omitting possible outliers by the interquartile range rule, did however not alter the conclusion; levels of Trp, alpha-ketoglutarate and the PAr Index remained significantly associated with CF and Kyn/Trp ratios were of borderline significance only.

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