According to the confocal microscopy images, the fluorescence signal intensity that was generated by calcein AM showed an increasing trend after treatment with either an increasing concentration (5 μg/mL, 25 μg/mL, and 50 μg/mL) of compound 160a (the calcein AM fluorescence signal intensity showed a dose-dependent behavior) or verapamil in the doxorubicin-resistant A549 cell line.
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Development of a Novel Quinoline Derivative as a P-Glycoprotein Inhibitor to Reverse Multidrug Resistance in Cancer Cells.
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