Noninvasive rapid detection of metabolic adaptation in activated human T lymphocytes by hyperpolarized ¹³C magnetic resonance.

The statistical analysis of the LC-MS measurements shows a highly significant increase (p = 0.004) of the [2,3- 13 C 2 ]lactate-to-[2,3- 13 C 2 ]pyruvate ratio upon activation, with a 95% confidence interval of [4.54, 28.76] (Fig. 3F ).

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