CpG Frequency in the 5' Third of the <i>env</i> Gene Determines Sensitivity of Primary HIV-1 Strains to the Zinc-Finger Antiviral Protein.

However, in contrast to the results obtained in transfected HEK293T cells, the correlations failed to reach significance, most likely because the number of HIV-1 constructs analyzed was limited and the inhibitory effects were less robust than those obtained in ZAP overexpression assays.

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We found a highly significant correlation between the minimum free energy of the predicted RNA structures of this part of the env gene and HIV-1 ZAP sensitivity ( Fig. 8A ).

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