highly significantp < 0.001
Carbachol delivery to PFC during sevoflurane anesthesia produced a highly significant increase in the local acetylcholine levels [mean ± SD (CI): 1.57 ± 0.92 (0.66–2.47), p < 0.001 compared with sevoflurane anesthesia], which remained significantly elevated during post-sevoflurane recovery period [mean ± SD (CI): 1.13 ± 0.87 (0.29–1.99), p = 0.007 compared with sevoflurane].