The Epstein-Barr virus nuclear antigen-1 upregulates the cellular antioxidant defense to enable B-cell growth transformation and immortalization.

However, while treatment with MTH1 inhibitors has only a small effect in the EBV-negative cells, EBV carriage was associated with a highly significant and reproducible three- to four-fold increase in the number of γH2AX positive cells (Fig. 6a, b lower panels and Fig. 6d ).

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