An interesting trend was observed for halogenated derivatives 2c,d, and 4 (Cl and Br): the presence of halogen induced the position of indolizine within the binding pocket by orienting the benzoyl ring toward the pocket made by the amino acid residue VAL 123.
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Anti-Tubercular Activity of Substituted 7-Methyl and 7-Formylindolizines and In Silico Study for Prospective Molecular Target Identification.
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