As shown in Figure 1 H, there was an increasing trend in circCELSR1 levels from normal ovarian tissues to PTX-sensitive ovarian cancer tissues and then to PTX-resistant ovarian cancer tissues, and the differences among the three groups were significant (p < 0.001).
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circCELSR1 (hsa_circ_0063809) Contributes to Paclitaxel Resistance of Ovarian Cancer Cells by Regulating FOXR2 Expression via miR-1252.
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The quantitative real-time PCR analysis indicated that there was a decreasing trend in miR-1252 levels from normal ovarian tissues to PTX-sensitive ovarian cancer tissues and then to PTX-resistant ovarian cancer tissues, and the differences among the three groups were significant (p < 0.01, Figure 4 H).