Tuning of NK-Specific HLA-C Expression by Alternative mRNA Splicing.

Front Immunol · 2019 · PMC6966967 · PMID 31998314

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may be significantno p-value reported

This observation predicts that the NK cell-mediated anti-leukemia effect would be greatest in individuals with HLA-C alleles lacking NK-Pro activity ( HLA-C * 02, -C * 05, -C * 07, -C * 08, -C * 17 ) and lowest in individuals that possess HLA-C * 06 together with the C2-binding KIR2DL1 inhibitory receptor, a factor that may be significant when choosing donors for stem cell transplantation.

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