Thus, it appears that there is likely to be significant overlap in monocyte uptake mechanisms between MVs and exogenously administered immunomodulatory microparticles (e.g. i.v.-injected mesenchymal stem cell-derived MVs or synthetic microparticles), which would be an important consideration for such therapeutic interventions.
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Monocytes mediate homing of circulating microvesicles to the pulmonary vasculature during low-grade systemic inflammation.
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