Reduced Expression of Genes Regulating Cohesion Induces Chromosome Instability that May Promote Cancer and Impact Patient Outcomes.

Sci Rep · 2020 · PMC6969069 · PMID 31953484

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may be significantno p-value reported

In particular, reduced expression of SMC3 , RAD21 , NIPBL and ESCO2 induced substantial cohesion defects and numerical CIN, and thus, may be significant, yet unappreciated drivers of cellular transformation and oncogenesis.

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