Enhancing Betulinic Acid Dissolution Rate and Improving Antitumor Activity via Nanosuspension Constructed by Anti-Solvent Technique.

Analysis of variance in Tables 3 and 4 showed that X 1 , X 3 , X 1 X 3 , X 1 2 and X 2 2 were extremely significant in Model Y 1 , while other items were insignificant; X 3 and X 1 X 2 in Model Y 2 were remarkably significant compared to other groups, X 1 2 was relatively significant, but likewise other items were insignificant.

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The model terms with p<0.01 and 0.01<p<0.05 indicated highly significant and significant, respectively.

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