An Updated Systematic Review With Meta-Analysis Of Randomized Trials On Topical Cyclosporin A For Dry-Eye Disease.

Drug Des Devel Ther · 2020 · PMC6974131 · PMID 32021110

Europe PMC DOI

hedged sentences

0.5800

closest p · 11.6× alpha

0.5800

boldest claim

The sentences

a positive trendP =0.58not close (p > 0.1)

Results of meta-regression showed that mean age was not significantly associated with MD in TBUT scores between CsA and ATs and showed a positive trend (point estimate 0.03, P =0.58, online supplementary file 9 ).

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a favorable trendno p-value reported

Five RCTs recruiting 269 cases with DED provided usable data on Schirmer’s test scores, 25 , 28 , 30 , 34 , 36 and pooled results showed no significant difference between the two groups, but a favorable trend for CsA over ATs (WMD 0.45, 95% CI −2.25 to 3.15).

also in 1,335 other papers

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