STARD1 and NPC1 expression as pathological markers associated with astrogliosis in post-mortem brains from patients with Alzheimer's disease and Down syndrome.

As expected, Aβ 42 deposition revealed a highly significant AUC with a high accuracy not only to identify AD and/or DS samples as positive (sensitivity), particularly in CA1 hippocampal areas, but also to identify the control subjects (specificity) in all hippocampal regions from DS-brains ( Figure 3 ).

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