Chronic sleep fragmentation shares similar pathogenesis with neurodegenerative diseases: Endosome-autophagosome-lysosome pathway dysfunction and microglia-mediated neuroinflammation.

53 , 54 It was reported highly significant, 2‐ to 5‐fold elevation in microglia number and area within Aβ deposits compared with neighboring regions in transgenic mouse models of AD. 55 The density of activated microglia correlates with the severity of the inflammatory response. 56 In this study, we found that activation of microglia after CSF predominately occurs in the hippocampus of mice.

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