The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly.

The Alzheimer’s disease PRS as originally reported lacked the highly significant APOE locus; accordingly this locus was manually added to the PRS using the tag SNP rs10414043, and an estimated β = 1.34 (ref. 62 ). rs10414043 was used in preference to the more conventional rs429358 as the latter was not robustly genotyped on all platforms.

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