Investigation of toll-like receptor (TLR) 4 inhibitor TAK-242 as a new potential anti-rheumatoid arthritis drug.

Arthritis Res Ther · 2020 · PMC6979396 · PMID 31973752

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However, treatment of rats with established clinical signs of arthritis with TAK-242 at 5 mg/kg resulted in a highly significant reduction in mRNA expression levels of NF-κB-p65 and AP-1 when compared to arthritic rats and rats treated with TAK-242 at 3 mg/kg.

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