Integrated 16S rRNA Sequencing, Metagenomics, and Metabolomics to Characterize Gut Microbial Composition, Function, and Fecal Metabolic Phenotype in Non-obese Type 2 Diabetic Goto-Kakizaki Rats.

The OPLS-DA score plot showed clear discrimination between two groups with [ R 2 X (cum) = 0.435, R 2 Y (cum) = 0.977, Q 2 (cum) = 0.972], which suggested that the model was predictive and reliable, and that differences in metabolites’ abundance between GK and Wistar rats were highly significant ( Figure 7B ).

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