Zika virus promotes CCN1 expression via the CaMKIIα-CREB pathway in astrocytes.

Virulence · 2020 · PMC6984649 · PMID 31957543

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an increasing trendno p-value reported

When the HA-CaMKIIα-transfected CCF-STTG1 cells were infected with ZIKV, the phosphorylation of CREB Ser133 showed an increasing trend that correlated with the transfection dose of HA-CaMKIIα plasmids; moreover, a unique up-regulating trend was observed for the expression of CCN1 protein.The ZIKV-E protein shows an increasing trend as well ( Figure 8(c) ).

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