Extracellular matrix anisotropy is determined by TFAP2C-dependent regulation of cell collisions.

Figure 6c shows that 5/6 of the predicted classes of compound had clear effects on ECM organisation, with MEK and Hsp90 inhibition having particularly strong effects ( Supplementary Figure 6b shows additional drugs with the same molecular targets); in contrast only 4/21 of a ‘control’ set of compounds had any effect ( Supplementary Figure 6c ), which is a highly significant enrichment p<0.005 (Chi-square).

also in 132,142 other papers