Arctigenin inhibits prostate tumor growth in high-fat diet fed mice through dual actions on adipose tissue and tumor.

Body weights in HF arctigenin group were comparable to that of LF non-tumor bearing mice, while body weights of HF control mice showed a slight trend while not statistically significant decrease starting 3 weeks post tumor inoculation (Fig. 5A ).

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This suggests that cancer cells may be able to induce the release of free fatty acid from adipocytes to satisfy their growth need, and this may eventually lead to a state of cachexia as a sign of which in this study was a decreasing trend in body weights of HF control mice after three weeks of tumor growth.

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