Another, 14 which assessed the effects of treatment in fewer RCTs (ie, 4 RCTs involving 54 493 participants, 5764 fractures, and 486 hip fractures), reported a borderline significant reduction in risk of any fracture (hazard ratio, 0.92; 95% CI, 0.86-0.99) and hip fracture (hazard ratio, 0.84; 95% CI, 0.70-1.01).
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Vitamin D and Calcium for the Prevention of Fracture: A Systematic Review and Meta-analysis.
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The sentences
Marginally significant lower risks of hip fracture were also observed in RCTs among older participants living in institutions ( P for heterogeneity = .07) and in those achieving greater treatment differences in 25(OH)D concentration ( P for heterogeneity = .08).